Paul Robustelli, Ph.D.

Assistant Professor; Dartmouth College

Portrait of Paul Robustelli

Paul Robustelli, Ph.D. is an assistant professor of chemistry at Dartmouth College, where his research focuses on the integration of computational and experimental methods to study dynamic and disordered proteins. Dr. Robustelli utilizes computer simulations and nuclear magnetic resonance (NMR) spectroscopy to model the conformational ensembles of intrinsically disordered proteins at atomic resolution to understand how small molecule drugs bind and inhibit disordered proteins and rationally design novel disordered protein inhibitors. Dr. Robustelli has made contributions to the development of physical models (“force fields”) that enable accurate simulations of disordered proteins and computational methods to integrate NMR data as restraints in molecular simulations.

Dr. Robustelli’s honors and awards include a National Science Foundation (NSF) Postdoctoral Research Fellowship, an NSF Graduate Research Fellowship and a Gates Cambridge Scholarship. Dr. Robustelli earned his B.A. in chemistry from Pomona College and his Ph.D. in chemistry from the University of Cambridge. He was also a postdoctoral fellow at Columbia University and a scientist at D.E. Shaw Research in New York.