Director, Target Selection and Strategy

Location: Roivant Discovery 451 D Street, Boston, MA 02210 USA

At Roivant, we are passionate about discovering and developing new drugs to impact patients' lives. Since its inception in 2014, Roivant has launched over 20 portfolio companies (Vants), overseen 5 successful IPOs, established a $3B partnership with a global pharma, built a pipeline of over 40 assets across various modalities and therapeutic areas, and delivered 8 successful phase 3 readouts. Roivant is currently building new capabilities in drug discovery and expanding its existing development engine to become the world's leading tech-enabled pharmaceutical company.

Roivant's drug discovery capabilities are driven by our computational discovery platform, which combines preeminent physics-based tools with deep expertise in machine learning to generate unprecedented predictive power that can tackle previously intractable discovery challenges. The tight integration of this computational platform with our experimental capabilities enables the rapid design and optimization of new drugs to address a wide range of targets for diseases with high unmet need.

We believe that the future of drug discovery lies in integrating predictive sciences, biology and medicinal chemistry to accelerate the path to new medicines. This role is an opportunity to be an architect of this paradigm shift and generate transformative benefit for patients.

Job Responsibilities

  • Provide scientific leadership in biology and translational medicine for the selection of therapeutic targets to the drug discovery portfolio
  • Surface and evaluate drug targets with a strong biological rationale and fit for our unique discovery platform integrating computation and  experimentation
  • Lead development of projects from target identification to drug discovery project plan development, working with a multidisciplinary team including experts in disease biology, genetics, biophysics, chemistry, biophysics, computational and commercial.
  • Engage with KOLs to define key targets in the context of disease and patient populations with unmet medical need to identify drug discovery opportunities
  • Collaborate with technical experts to develop data-mining approaches for target identification using multi-omic ,molecular profiling data integrated with clinical and phenotypic data
  • Provide expertise in search, evaluation and due diligence for in-licensing of innovative, high value assets
  • Serve as a strategic thought leader in emerging areas of biology, medicine, and innovation; leveraging a strong network of thought leaders to capitalize on emerging science and translate to breakthrough medicines

 

Requirements

  • PhD in biology, genetics, biochemistry, pharmacology or related fields followed by postdoctoral training and 7+ years of industrial drug discovery experience
  • Deep knowledge of pathway/disease biology and causal drivers of disease
  • Demonstrated record delivering target nominations leading to clinic development
  • Track record of deliveries and impact in drug discovery projects
  • Interest in exploring emerging areas of biology and ability to critically assess opportunities for strategic investment for drug discovery
  • Ability to contribute to strategy and distill to target selection
  • Excellent leadership skills with ability to energize and inspire teams across disciplines
  • Ability to work independently and collaborate in a fast-paced team environment
  • Highly organized, detailed-oriented with excellent communication skills
  • Proven record of innovative thinking and a willingness to champion new ideas and solutions
  • Views the toughest challenges as the greatest opportunities for personal growth and company innovation
  • Demonstrates tenacity and willingness to go the distance to achieve goals
  • Commitment to building a world-class drug discovery organization

 

 

 

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