Senior Director/Director, Medicinal Chemistry

Location: Roivant Discovery 451 D Street, Boston, MA 02210 USA

At Roivant, we are passionate about discovering and developing new drugs to impact patients’ lives. Since its inception in 2014, Roivant has launched over 20 portfolio companies (Vants), overseen 5 successful IPOs, established a $3B partnership with a global pharma, built a pipeline of over 40 assets across various modalities and therapeutic areas, and delivered 8 successful phase 3 readouts. Roivant is currently building new capabilities in drug discovery and expanding its existing development engine to become the world’s leading tech-enabled pharmaceutical company.

Roivant’s drug discovery capabilities are driven by our computational discovery platform, which combines preeminent physics-based tools with deep expertise in machine learning to generate unprecedented predictive power that can tackle previously intractable discovery challenges. The tight integration of this computational platform with our experimental capabilities enables the rapid design and optimization of new drugs to address a wide range of targets for diseases with high unmet need.

We believe that the future of drug discovery lies in integrating predictive sciences, biology and medicinal chemistry to accelerate the path to new medicines. This role is an opportunity to be an architect of this paradigm shift and generate transformative benefit for patients.

Position Summary: 

We are looking for an experienced, innovative and highly motivated Sr. Dir/Director of Medicinal Chemistry to lead a team within our Chemistry and Applied Modeling group.

Responsibilities:

  • Lead and develop a team of outstanding medicinal chemists focused on the design, synthesis, and optimization of innovative small/heterobifunctional molecules from hit identification to candidate selection
  • Provide direct strategic and tactical input on the medicinal chemistry strategy for the rapid progression of portfolio projects.
  • Contribute to target selection and hit/lead finding strategies including the use of structure-based drug design and fragment-based drug discovery
  • Establish and maintain a clear understanding of the internal computational capabilities, and how to apply these tools to support new compound design.
  • Manage CRO chemistry teams through excellent synthetic and medical chemistry troubleshooting, with clear and open collaboration.
  • Mentor other members of the Chemistry and Applied Modeling team on key aspects of advancing programs from target validation though lead optimization and delivering clinical

Requirements:

  • PhD with 8+ years’ experience working in a pharmaceutical and/or biotechnology setting as a medicinal chemist or equivalent experience.
  •  A strong track record of successfully advancing multiple drug discovery programs from target validation though lead optimization and delivering clinical candidates.
  • Knowledge and awareness of advancing compounds from lead optimization to development candidate, including optimization of critical ADME and PK properties for human translation, advanced compound profiling and interpretation of in vivo studies.
  • Highly knowledgeable in the understanding of the relationship between physiochemical and ADME properties on drug exposure, and the integration of this information into compound design and profiling.
  • Experience using structure-based drug design and closely collaborating with computational chemists and modelers to prioritize compound designs for synthesis and drive compound
  • High-level understanding of how compound design/chemistry integration supports project teams goals, timelines, and deliverables.
  • Experience in managing external and internal chemistry resources to ensure maximum productivity and efficiency and the ability to manage timelines and resources to drive projects toward key decision c criteria.
  • A track record of technical excellence as shown by peer reviewed publications and inventorship status on patents.

At Roivant, our goal is to improve human health by rapidly discovering, developing and delivering innovative medicines and technologies to all patients. Our success is predicated on attracting and retaining top talent, generating new ideas and promoting an open and collaborative culture.

We embrace diversity across all dimensions and levels of the organization and we strive to ensure every employee is supported in reaching their full potential. We hire motivated people with diverse backgrounds, identities, experiences and skillsets. We are committed to fostering an inclusive culture where all employees feel valued, respected and empowered to create value for patients.

Roivant Sciences provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

 

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