Senior/Principal Investigator, Computational Biology and Genomics

Location: Roivant Discovery 451 D Street, Boston, MA 02210 USA

At Roivant, we are passionate about discovering and developing new drugs to impact patients’ lives. Since its inception in 2014, Roivant has launched over 20 portfolio companies (Vants), overseen 5 successful IPOs, established a $3B partnership with a global pharma, built a pipeline of over 40 assets across various modalities and therapeutic areas, and delivered 8 successful phase 3 readouts. Roivant is currently building new capabilities in drug discovery and expanding its existing development engine to become the world’s leading tech-enabled pharmaceutical company

Roivant’s drug discovery capabilities are driven by our computational discovery platform, which combines preeminent physics-based tools with deep expertise in machine learning to generate unprecedented analytical power that can tackle previously intractable discovery challenges. The tight integration of this computational platform with our experimental capabilities enables the rapid design and optimization of new drugs to address a wide range of targets for diseases with high unmet need.

We believe that the future of drug discovery lies in integrating predictive sciences, biology and medicinal chemistry to accelerate the path to new medicines. This role is an opportunity to be an architect of this paradigm shift and generate transformative benefit for patients.

Position Summary:  

Roivant Sciences is seeking an exceptional scientist at the intersection of genomics and computational biology, to translate molecular profiling data into high value insights for structure-based design of precision medicines in multiple disease areas including oncology and inflammatory diseases. This individual will have a critical, high impact role in guiding target selection and biomarker identification for patient selection. This will include close collaboration with Roivant’s industry leading physics and machine learning based computational platform. A key objective will be to integrate disease relevant sequence variants with protein structure and dynamics to understand conformational states to modulate therapeutically (conformational genetics). Additionally, this role will involve defining further growth in genomics and computational biology capabilities.

Key Responsibilities: 

  • Integrated datamining of genomics datasets including somatic and germline next generation sequencing (NGS) data including whole genome, exome DNA-seq, bulk and single cell RNA-seq, and chromatin profiling
  • Analysis of genotype/phenotype relationships to establish gene and variant level therapeutic relevance for precision medicine-based drug design
  • Mapping genetic variants to protein to predict impact on structure, conformational states and function
  • Target selection in collaboration with a multidisciplinary team; prioritizing genetically validated targets for entry into the drug discovery portfolio
  • Genomic biomarker discovery to identify patients for precision medicines
  • Evaluation of emerging platform technologies in genomics, computational biology and related areas; providing expert technical input to guide Roivant investments

Requirements: 

  • PhD or MD/PhD degree in the area of genomics and/or computational biology
  • 3+ years post-PhD research experience in industry or academia
  • Excellence in bioinformatic analysis of large scale somatic, germline genetics and gene expression datasets
  • Experience in design and analysis of genome level NGS experiments
  • Experience in drug discovery preferred
  • Experience in fast paced, start-up environments is preferred – able to work comfortably under pressure, frequently changing landscape and tight deadlines
  • A strategic thinker with excellent business judgment
  • Highly motivated and willing to take on multiple responsibilities at once
  • Resourceful and relentless: independently capable of seeking information, solving conceptual problems, corralling resources, and delivering results in challenging situations
  • Highly Innovative problem solver possessing strong interpersonal, multi-tasking, organizational, project planning skills, and a demonstrated ability to meet aggressive deadlines
  • Excellent verbal and written communication skills; ability to deal with complex problems and present recommendations and findings in a clear, concise format
  • Quick and scrappy learner who adapts well to a fast-moving environment and gets things done, combines creativity, problem-solving skills, and a can-do attitude to overcome any obstacle
  • Highly proficient in Python and R software

 

Roivant Sciences provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

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